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Contraindicated (1)pentobarbital will lower the level or outcome of lorlatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the extent or impact of midostaurin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Strong CYP3A4 inducers may possibly lower midostauri